The home of blues, country, soul and Elvis Presley: music lovers will be in their element when travelling in and around Chicago, Nashville and Memphis.
You won't go hungry either – with those famous deep-dish pizzas in the Windy City, old-school diners serving comfort food fit for the King, and plenty of southern cooking.
Whether you are planning a short city break or an extensive road trip with friends, family or your partner, our panel of local experts are here to help. Based across Illinois and Tennessee, they have amassed a lifetime of tips. You can pick their brains on where to stay, where to eat, where to visit for day trips and how to get to all those places you know from song lyrics.
Leave your questions in the comment section below and come back to join us on Wednesday 21 August, between 4pm and 5pm BST (10am CT in the US), when they'll be spilling their insider knowledge.
Post a question below, or tweet us your questions at @guardiantravel
Meet the experts
Karla Zimmerman lives in Chicago and writes about her home base for Lonely Planet, the BBC and many others. She has created the Chicago Free & Frugal app and blogs at mykindoftownandaround.blogspot.com. Follow her on Twitter at @karlazimmerman.
Margaret Littman is a Nashville-based writer and editor (littmanwrites.com). She is the author of the Nashville Essential Guide (an iPhone and Android app) and many travel guidebooks, including Moon Tennessee and the upcoming Moon Nashville.
Christine des Garennes is an Ilinois-based news reporter and travel writer. She is the author of the Moon guide to Illinois and also runs Midwest by Minivan, a family travel site.
Jaime Black is based in Chicago and has been working within its music scene for 15 years, racking up a wealth of know-how on where to catch the best gigs. He is the founder and host of the city's longest-running music-focused podcast, Dynasty Podcasts.
Tammy Mercure (tammymercure.com) is a photographer living in Nashville, TN, who has travelled widely in the region. She's particularly clued up on the arts and unusual local events.
Questions from readers via Twitter (@Guardiantravel):
And we seem to be going multilingual with this Q&A. This reader – and big Elvis fan – in Spain would like to know what the climate will be like in September. Perhaps our experts will also be able to offer some advice on what to pack?
We're not sure that our experts will be able to help with the following one, but you never know, they are good.